Personal molecular information is transforming healthcare, prompting such initiatives as the Cancer Moonshot Project 2020, 21st Century Cures and the Precision Medicine Initiative. The cost of next-generation sequencing and other techniques that provide comprehensive whole-patient data is decreasing rapidly, making personalized multi-omics analysis increasingly cost effective and accessible. At the same time, using multi-omics data in developing an informed, personalized approach to treatment, access to effective clinical trials and preventive strategies can provide major cost savings in terms of avoiding ineffective treatments, expensive diagnostic regimens, etc. With affordable whole-patient scale data just around the corner, the challenge has now moved into the realm of extraction of meaningful insights from the data. Pine Biotech provides an analytics layer that integrates clinical knowledge with multi-omics raw data analysis for biomarker discovery and personalized molecular features that can guide individualized treatment. Our tools work in a synchronized way across clinical care, clinical trials and research for a full ecosystem that supports innovative precision medicine approaches to healthcare.